Bacterial or Non-Bacterial Infection?
FebriDx® aids in the differentiation between bacterial infection and non-bacterial etiology.

Acute respiratory infections, causing symptoms such as common cold, sore throat, cough, congestion and runny nose, are the most common reason for seeking medical advice and antibiotic prescriptions.1-3 Differentiating between bacterial infection and non-bacterial etiology can be challenging due to an overlap in signs and symptoms of bacterial and non-bacterial infections.

The majority of acute respiratory infections are caused by viruses and do not require antibiotics, yet antibiotics are prescribed in up to 50% of cases.4 Antibiotic resistance continues to remain a major global health threat contributing to 2.8 million antibiotic-resistant illnesses and 35,000 deaths each year in the U.S.5

Introducing FebriDx® Point-of-Care Test Device
FebriDx® is a rapid point-of-care test that uses a fingerstick blood sample to aid in the differentiation between bacterial infection and non-bacterial etiology. FebriDx® is intended to be used in urgent and emergency care settings.

Knowing whether a patient has a bacterial infection has a direct impact on reducing unnecessary antibiotic prescriptions, limiting the spread of antibiotic-resistant bacteria, and helping providers know when to initiate treatment.

  • Results after 10 minutes increases confidence in whether or not to prescribe an antibiotic.

  • Highly sensitive/specific dual biomarker technology provides reliable differentiation of bacterial and non-bacterial infections.

  • All-in-one, instrument-free test device means no expensive equipment and a fully portable solution.

Using FebriDx® during a patient visit can reduce diagnostic uncertainty and help guide appropriate patient management and reduce inappropriate antibiotics. Results are available after 10 minutes, allowing the clinician to provide a timely and targeted treatment plan during the initial visit.
  • Increase confidence in decision making
    Confidently rule out a bacterial infection with 99% negative predictive value (NPV)6,7

  • Ensure bacterial infections are not overlooked
    Increased confidence in patient diagnosis

  • Improve patient satisfaction
    Support patient understanding of treatment plan with a tangible test result

  • Enable improved patient management
    Actionable results after 10 minutes for use during a patient visit

  • Support antimicrobial stewardship
    Reduce unnecessary antibiotic use6-9

  1. Harris AM, Hicks LA, Qaseem A. Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. Mar 15 2016;164(6):425-34. doi:10.7326/m15-1840.
  2. Centers for Disease Control and Prevention (CDC). National Ambulatory Medical Care Survey: 2019 National Summary Tables.
  3. Renati S, Linder JA. Necessity of office visits for acute respiratory infections in primary care. Fam Pract. 2016;33(3):312-317.
  4. Fleming-Dutra, K. E., Hersh, A. L., Shapiro, D. J., Bartoces, M., Enns, E. A., File, T. M., ... & Hicks, L. A. (2016). Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011. JAMA. 315(17), 1864-1873.
  5. Centers for Disease Control and Prevention (CDC). Antibiotic Resistance Threats in the United States. 2019. Accessed August 2023.
  6. Shapiro NI, Self WH, Rosen J, et al. A prospective, multi-centre US clinical trial to determine accuracy of FebriDx point-of-care testing for acute upper respiratory infections with and without a confirmed fever. Ann Med. Aug 2018;50(5):420-429. doi:10.1080/07853890.2018.1474002
  7. Shapiro NI, Filbin MR, Hou PC, et al. Diagnostic Accuracy of a Bacterial and Viral Biomarker Point-of-Care Test in the Outpatient Setting. JAMA Network Open. 2022;5(10):e2234588-e2234588. doi:10.1001/jamanetworkopen.2022.34588
  8. Davidson M. FebriDx point-of-care testing to guide antibiotic therapy for acute respiratory tract infection in UK primary care: a retrospective outcome analysis. J Infect Dis Preve Med. 2017;5(3):165.
  9. Carlton HC, Savović J, Dawson S, Mitchelmore PJ, Elwenspoek MM. Novel point-of-care biomarker combination tests to differentiate acute bacterial from viral respiratory tract infections to guide antibiotic prescribing: A systematic review. Clin Microbiol Infect. 2021;

Contact us to learn more about FebriDx.